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Djekson 磁力大全. Klinicheskaya farmakologiya. Kd 2128 pasport stanka. Uchebnik (Russian) Hardcover – 2015. (red.) Kukes V. (Author) Be the first to review this item. See all formats and editions Hide other formats and editions. Price New from Used from Hardcover, 2015 'Please retry' $159.40.

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It is known that cadmium has the ability to supersede biometals from the protein structures, inhibits the catalytic properties of the enzymes, depresses innate immunity factors, exacerbates the infectious process. The aim of this work was to explore the dynamics of the specific antibodies synthesis in M.bovis infected rabbits and the impact of intoxication with low doses of cadmium chloride on it. Materials and methods. The animals were divided into 4 groups, three rabbits each. The chronic intoxication was caused by using cadmium chloride the aqueous solution of which was administered orally to rabbits of groups 1 and 3 daily for 60 days in a dose of 1.5 mg/kg.

The animals of groups 2 and 4 received placebo. After 14 days from the beginning of the experiment rabbits of groups 2 and 3 were infected with M.bovis Bovinus-8. The antibody genesis dynamics was determined using indirect enzyme-linked immunosorbent assay (ELISA) based on home-made antigens and multiplex immunoassay. The diagnostic significance of the antigens was confirmed by analytical electrophoresis and immunoblot. The antibody response of infected animals (group 2) was detected since the 14th day after inoculation.Thus level of serum antibodies was stable until the end of the observation period (42 days), and the optical density reached 1.177 OD with M.bovis Bovinus-8 cell extract and 0.238 OD with their secondary metabolites. There was a specific antibody synthesis delay of up to 28-42 days in rabbits infected after preliminary intoxication (group 3). ELISA results of uninfected animals (groups 1 and 4) did not exceed 0.179 OD and 0.078 OD for those antigens, respectively.